Vancomycin: ligand recognition, dimerization and super-complex formation
نویسندگان
چکیده
منابع مشابه
A ligand-mediated dimerization mode for vancomycin.
BACKGROUND Vancomycin and related glycopeptide antibiotics exert their antimicrobial effect by binding to carboxy-terminal peptide targets in the bacterial cell wall and preventing the biosynthesis of peptidoglycan. Bacteria can resist the action of these agents by replacing the peptide targets with depsipeptides. Rational efforts to design new agents effective against resistant bacteria requir...
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The retention and separation of D,L-dansylvaline enantiomers (used as test solutes) were investigated using silica gel as stationary phase and vancomycin as chiral mobile-phase additive. A retention model was developed to describe the mechanistic aspects of the interaction between solute and vancomycin in the chromatographic system. It considered the formation of vancomycin dimers both "free" i...
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The complexation reaction between salen (Bis(salicylidene)ethylenediamine) and Cu(II) cations in methanol (MeOH), 2-propanol (2-PrOH), acetonitrile (AN), tetrahydrofuran (THF), and chloroform (CHCl3) as nonaqueous solvents at 25º C has been investigated. The stoichiometry and formation constants of complexes have been determined spectrophotometrically and conductometrically by method of continu...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2013
ISSN: 1742-464X
DOI: 10.1111/febs.12121